Cost-Effective Designs for Linkage Disequilibrium Mapping of Complex Traits

Multi-loci Linkage Disequilibrium Mapping of Complex Traits

In genetics, linkage disequilibrium (LD) is a phenomenon arising from the co-inheritance of alleles at nearby loci on the same chromosome, i.e., the alleles at multiple tightly linked genetic loci pass nonrandomly from generation to generation in a natural population. Capitalizing on this phenomenon, a group of mapping methods, called LD mapping, have been developed recently for genetic associa...

Bolck Linkage Disequilibrium Mapping

1. Abstract 2. Introduction 3. Models and methods 3.1. Haplotype block characterization 3.2. Measure of haplotype block LD 3.3. Test statistic and power calculation 3.4. Population genetic model of haplotype block 4. Results 4.1. Haplotype block LD measure 4.2. Power of the haplotype block LD mapping 4.3. Mapping 5. Discussion 6. Appendix 6.1. Appendix A 6.2. Appendix B 6.3. Appendix C 7. Refer...

Linkage disequilibrium mapping of complex disease: fantasy or reality?

In the past year, data about the level and nature of linkage disequilibrium between alleles of tightly linked SNPs have started to become available. Furthermore, increasing evidence of allelic heterogeneity at the loci predisposing to complex disease has been observed, which has lead to initial attempts to develop methods of linkage disequilibrium detection allowing for this difficulty. It has ...

Shaking the tree: mapping complex disease genes with linkage disequilibrium.

Much effort and expense are being spent internationally to detect genetic polymorphisms contributing to susceptibility to complex human disease. Concomitantly, the technology for detecting and genotyping single nucleotide polymorphisms (SNPs) has undergone rapid development, yielding extensive catalogues of these polymorphisms across the genome. Population-based maps of the correlations amongst...

linkage disequilibrium and association mapping